The Y chromosome gr/gr subdeletion is associated with male infertility
نویسندگان
چکیده
منابع مشابه
Y chromosome and male infertility.
Recent genome analysis of the Y chromosome has increased the number of genes found on this chromosome markedly. Many of these genes in the part of the Y chromosome that does not undergo recombination with the X chromosome are members of gene families. Evolutionary considerations imply that genes on the Y chromosome will degenerate unless they have male advantageous or female deleterious functio...
متن کاملA frequent Y chromosome b2/b3 subdeletion shows strong association with male infertility in Han-Chinese population.
BACKGROUND Azoospermia factor c (AZFc) subdeletions were reported to be significant risk factors for spermatogenesis. In this study, we assessed the occurrence of classical AZF deletions and AZFc subdeletions and their impact on male infertility in a Han-Chinese population. METHODS This study analysed a population of 699 subjects, including 451 idiopathic infertile patients with a range of fe...
متن کامل[Y chromosome microdeletions in male infertility].
A genetic basis of infertility may exist in many men currently classified as having idiopathic infertility. Approximately 7% of infertile men harbour submicroscopic deletions of the Y chromosome that are not detectable on routine karyotype. Two candidate gene families, namely the RNA-binding motif-containing gene family, and the deleted-in-azoospermia gene family, have been cloned by deletion m...
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As you know, for penile erection, a sufficient amount of testosterone-induced nitric oxide is needed in the smooth muscle of the penile arterial wall. With aging, LOH syndrome and so on, the serum testosterone level decreases, resulting in a decline of penile erectile function. Furthermore, it is known that the enzyme PDE5 in the penile artery wall also inhibits that function. Even so, it may b...
متن کاملThe Y chromosome and male fertility and infertility.
Since 1995, thanks to a large number of studies, Y chromosome microdeletion screening has become part of the routine diagnostic work-up of severe male factor infertility. Many initial contradictory issues such as variability in deletion frequency, markers to be tested, presence of deletions in 'fertile' men, and genotype-phenotype correlation has been resolved. Past and present unresolved issue...
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ژورنال
عنوان ژورنال: MHR: Basic science of reproductive medicine
سال: 2005
ISSN: 1460-2407,1360-9947
DOI: 10.1093/molehr/gah191